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Confira os próximos eventos- Data de início do evento: 12/12/2019
TÍTULO: " Using natural diversity and genome engineering to understand centromere function"PALESTRANTE: Prof. William R. A. Brown, PhD - Nottingham University, United Kingdom
"The kinetochore is the evolutionarily conserved protein complex that is responsible for accurate chromosome segregation at cell division in eukaryotic cells. Despite conservation at the protein level, the kinetochore is associated with a variety of apparently unrelated DNA sequences even within the same organism. The is known as the “centromere paradox”. We are using a combination of genome engineering and a study of natural diversity to understand the “centromere paradox”. We have recently made progress in understanding the recognition of native centromeric DNA by the kinetochore. A particularly notable example of the kinetochore paradox is represented by the ability to jump from a native centromere to an apparently unrelated sequence. Such sequences are referred to as “neo-centromeres” at the population level and “evolutionarily novel centromeres” at the species level. Further progress in our field depends on developing a genetic assay for neo-centromere formation and we are trying to do this."
DATA Quinta-feira, 12/12/2019
HORÁRIO: 11h
LOCAL Sala Therezinha Ungaretti - Depto de Genética e Biologia Evolutiva do IB/USPLeia mais
- Data de início do evento: 09/12/2019
The kinetochore is the evolutionarily conserved protein complex that is responsible for accurate chromosome segregation at cell division in eukaryotic cells. Despite conservation at the protein level, the kinetochore is associated with a variety of apparently unrelated DNA sequences even within the same organism. The is known as the “centromere paradox”. We are using a combination of genome engineering and a study of natural diversity to understand the “centromere paradox”. We have recently made progress in understanding the recognition of native centromeric DNA by the kinetochore. A particularly notable example of the kinetochore paradox is represented by the ability to jump from a native centromere to an apparently unrelated sequence. Such sequences are referred to as “neo-centromeres” at the population level and “evolutionarily novel centromeres” at the species level. Further progress in our field depends on developing a genetic assay for neo-centromere formation and we are trying to do this."
Palestrante: Prof. William R. A. Brown, PhD : Nottingham University, United Kingdom
Data: 09.12.19
Hora: 13h
Local: Sala Therezinha Ungaretti - Depto de Genética e Biologia Evolutiva do IBUSP
- Data de início do evento: 05/12/2019
Comemoração Cinquentenário IB-USP, nossa história está em movimento, 05 de dezembro de 2019 – quinta-feira, Anfiteatro Geral da Zoologia e Tenda
